Thermo Fisher Scientific CD42b Monoclonal Antibody (HIP1), FITC, eBioscience
인간 CD42b(platelet gpIb) 인식 단클론 항체 HIP1, FITC 결합 형식. 유세포분석용으로 최적화되어 있으며 5 µL/test로 사용. 488 nm 흥분, 520 nm 방출 스펙트럼. 혈소판 활성화 및 응고 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (1 µg)/test | View 6 publications |
| Functional Assay (Functional) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIP1 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572453 |
Additional Formats Available
- Unconjugated
- APC
- NovaFluor Blue 510
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Yellow 610
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
Description:
The HIP1 monoclonal antibody reacts with the human CD42b molecule, a 135 kDa transmembrane protein also known as platelet gpIb.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of human platelets.
Recommended use: 5 µL (1 µg) per test in a final volume of 100 µL.
Cell number should be determined empirically (10⁵–10⁸ cells/test).
Spectral Properties:
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
CD42b is a platelet activation marker involved in coagulation as an aggregating factor. It interacts with extracellular matrix and adhesion molecules. CD42b expression and activation are regulated by VEGF and PDGF.
It forms part of the GPIb-IX-V receptor complex, critical for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces. CD42b binds to von Willebrand factor (VWF), thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin.
The extracellular domain contributes to metastasis. CD42b antigen is expressed on platelets and megakaryocytes. Mutations in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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