Thermo Fisher Scientific IL1A Monoclonal Antibody (OTI2F8), TrueMAB
IL1A 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, ICC/IF 등 다양한 응용 가능. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도. 인간 IL1A 전체 길이 재조합 단백질을 면역원으로 사용. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F8 |
| Immunogen | Full length human recombinant protein of human IL1A produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, shared with IL-1 beta.
Located on chromosome 2q13, IL-1 alpha plays a key role in innate host defense by inducing other proinflammatory cytokines and acute-phase responses.
IL-1 alpha activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which inhibits receptor binding competitively. This cytokine is involved in immune responses, inflammation, and hematopoiesis. It is produced as a proprotein by monocytes and macrophages, processed upon cell injury, and can induce apoptosis.
IL1A and other interleukin family genes form a cytokine cluster on chromosome 2. It regulates NF-kappaB and MAPK pathways, stimulates IL6 and COX-2 (PTGS2) expression, and enhances nitric oxide (NO) production. Elevated IL-1 alpha levels are linked to chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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