Thermo Fisher Scientific KMT2E Polyclonal Antibody
KMT2E 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC(P), ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific KMT2E Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human KMT2E (1–1858 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2720579 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
The mixed lineage leukemia (MLL) gene family comprises a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family. The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias.
MLL2 (also designated ALR) exists within a complex of proteins and is important for mouse embryonic development, possibly involved in adhesion-related cytoskeletal events affecting cell growth and survival.
The MLL2 gene maps to human locus 19q13.1, a frequent target of rearrangement or amplification in solid tumors.
MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), regulating ligand-dependent H3K4 trimethylation and expression of LXR-target genes.
MLL3 maps to human chromosome 7, often deleted in myeloid disorders, and shows higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus.
MLL5 localizes to the nucleus and forms intranuclear protein complexes that may regulate chromatin remodeling and cellular growth suppression. The human MLL5 gene lies within chromosome band 7q22.3, a region deleted in acute myeloid malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.