Thermo Fisher Scientific IL31RA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

IL-31 is a T cell cytokine preferentially produced by T helper type 2 cells. It signals through a heterodimeric receptor composed of IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3, and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited, contributing to activation of the MAP kinase pathway in response to IL-31.

Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Studies show higher IL-31R expression in epidermal keratinocytes from AD patients compared to healthy skin. IL-31 may play a role in itch sensation and scratching behavior in atopic dermatitis models and represents a potential target for antipruritic drug development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.