Thermo Fisher Scientific HOXB4 Recombinant Rabbit Monoclonal Antibody (ARC2236)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC2236

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HOXB4 (P17483) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HOXB4,uniProtId:P17483-1,ncbiNodeId:9606,antigenRange:1-100,antigenLength:251,antigenImageFileName:MA5-37955_HOXB4_P17483-1_Rabbit.svg,antigenImageFileNamePDP:MA5-37955_HOXB4_P17483-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.09 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897875

Product Specific Information

Positive Samples: 293T, K-562

Immunogen sequence: MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG

Target Information

HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.