Thermo Fisher Scientific HOXB4 Recombinant Rabbit Monoclonal Antibody (ARC2236)
HOXB4 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며, HEK293 세포 발현 시스템을 사용했습니다. PBS 기반 완충액에 보관되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2236 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human HOXB4 (P17483) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.09 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897875 |
Product Specific Information
- Positive Samples: 293T, K-562
- Immunogen sequence:
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG
Target Information
HOX homeobox genes play a role both in early stem cell function and in later stages of hematopoietic differentiation.
HOXB4 is a homeotic selector gene implicated in the self-renewal of definitive hematopoietic stem cells (HSCs).
Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induces a switch to the definitive HSC phenotype.
Activation of WNT signaling in HSCs increases HOXB4 expression, while perturbations of HOX gene expression can cause leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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