Thermo Fisher Scientific Progesterone Receptor Recombinant Rabbit Monoclonal Antibody (4Y4H5)
사람 프로게스테론 수용체(PR)를 검출하는 재조합 토끼 단클론 항체. Western blot 및 ELISA에 적합하며, HEK293 발현 시스템에서 생산. 고순도 친화 크로마토그래피 정제, PBS/glycerol 완충액에 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4Y4H5 |
| Immunogen | Recombinant fusion protein containing amino acids 260–330 of human Progesterone Receptor (NP_000917.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2897874 |
Product Specific Information
- Positive Samples: BT-474
- Immunogen sequence:
AAAGGVALVP KEDSRFSAPR VALVEQDAPM APGRSPLATT VMDFIHVPIL PLNHALLAAR TRQLLEDESY D
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events such as the establishment and maintenance of pregnancy.
PR exists as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to alternative translation initiation. PR-B is transcriptionally active, maintaining endometrial function and pregnancy, while PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes allow receptor dimerization and binding to progesterone response elements (PRE), activating transcription.
Null mutations in the PGR gene can lead to reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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