Thermo Fisher Scientific TRPM8 Polyclonal Antibody
TRPM8 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. 합성 펩타이드 항원을 이용해 제작되었으며, 비결합(Unconjugated) 형태로 제공. 냉각 감지 관련 연구 및 TRPM8 발현 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 1 publication |
| Immunohistochemistry (IHC) | 1:500 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat TRPM8, conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2208883 |
Product Specific Information
Reconstitute with 100 µL of distilled water.
Centrifuge to remove any insoluble material.
Target Information
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, being activated by cold temperature below 25°C. It is also activated by icilin, eucalyptol, menthol, and modulation of intracellular pH.
TRPM8 is permeable to monovalent cations (Na⁺, K⁺, Cs⁺) and divalent cation (Ca²⁺).
Expression is mostly restricted to prostate epithelial cells, with elevated expression in prostate cancer. TRPM8 mRNA is also found in several nonprostatic tumors (breast, colon, lung, skin), but rarely detected in corresponding normal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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