Thermo Fisher Scientific TRPV6 Polyclonal Antibody
TRPV6 단백질을 인식하는 Rabbit Polyclonal 항체로 Rat 시료에 반응. Western blot 및 Immunohistochemistry에 최적화. 합성 펩타이드 항원 기반으로 제작되어 높은 특이성 보유. 연구용으로 장기 보관 시 -20°C에서 안정적 유지.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (IHC) | 1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat TRPV6 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TRPV6.
Target Information
Calcium-permeable channels such as TRPV6 participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger.
Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 is a calcium selective cation channel involved in Ca(2+) uptake in various tissues, including intestinal Ca(2+) reabsorption.
The channel is activated by low internal calcium levels, possibly including intracellular calcium store depletion, and exhibits inward rectification.
Inactivation includes both rapid Ca(2+)-dependent and slower Ca(2+)-calmodulin-dependent mechanisms, which may be regulated by phosphorylation.
In vitro, it is slowly inhibited by Mg(2+) in a voltage-independent manner.
Heteromeric assembly with TRPV5 modifies channel properties; TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin.
Interaction with S100A10 is required for plasma membrane trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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