Thermo Fisher Scientific TRPV6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute with 100 µL of distilled water.
Centrifuge to remove any insoluble material.

Target Information

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger.
Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).

TRPV6 is a calcium-selective cation channel likely involved in Ca²⁺ uptake in various tissues, including intestinal calcium reabsorption.
The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation occurs via both rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent mechanisms, possibly regulated by phosphorylation.
In vitro, the channel is slowly inhibited by Mg²⁺ in a voltage-independent manner.

Heteromeric assembly with TRPV5 modifies channel properties; TRPV5-TRPV6 heteromultimers show voltage-dependent gating.
TRPV6 interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin.
The interaction with S100A10 is required for trafficking to the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.