Thermo Fisher Scientific DDIT3 Monoclonal Antibody (2C4)
DDIT3 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체(2C4). Western blot과 ELISA에 적합하며, 인간 시료에 반응합니다. PBS 용액 형태로 제공되며 방부제는 포함되어 있지 않습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C4 |
| Immunogen | DDIT3 (AAH03637.1, 94 a.a. approximately 155 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EEEEDQGRTR KRKQSGHSPA RAGKQRMKEK EQENERKVAQ LAEENERLKQ EIERLTREVE AT
Target Information
GADD153 is a small nuclear protein that can dimerize with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Conversely, the C/EBP–GADD153 dimer gains binding activity to other non-classical C/EBP stress-related targets. Under normal cellular conditions, this protein is not expressed at detectable levels but is highly upregulated during cellular or ER stress. Examples of GADD153-inducing stress include treatment with tunicamycin, nutrient starvation, and reducing agents that interfere with calcium flux across the ER membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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