Thermo Fisher Scientific GRK1 Polyclonal Antibody
GRK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ELISA 등 다양한 응용에 적합하며 인간, 마우스, 랫트 반응성을 보입니다. 고순도 Affinity chromatography로 정제된 액상 형태로 안정적 저장이 가능합니다.
- 판매단위
- pk
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Thermo Fisher Scientific GRK1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–160 of human GRK1 (NP_0029201) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.82 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901607 |
Product Specific Information
- Positive Samples: Jurkat, Mouse eye, Rat liver, Rat eye
- Immunogen sequence:
MDFGSLETVV ANSAFIAARG SFDGSSSQPS RDKKYLAKLK LPPLSKCESL RDSLSLEFES VCLEQPIGKK LFQQFLQSAE KHLPALELWK DIEDYDTADN DLQPQKAQTI LAQYLDPQAK LFCSFLDEGI VAKFKEGPVE IQDGLFQPLL QATLAHLGQA
Target Information
GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases.
It mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin, leading to its deactivation.
Defects in GRK1 are known to cause Oguchi disease 2 (stationary night blindness Oguchi type-2).
GRK1 can be phosphorylated by PKA, reducing its ability to phosphorylate rhodopsin in vitro.
Phosphorylation of GRK1 by PKA in vivo is speculated to occur in the dark when cAMP levels in photoreceptor cells are elevated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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