Thermo Fisher Scientific STAT5A Monoclonal Antibody (PCRP-STAT5A-1A11)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1–2 µg/10^6 cells

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody is predicted to work with Mouse and Rat.

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and essential for tumorigenesis. The mouse counterpart induces expression of BCL2L1/BCL-X(L), suggesting anti-apoptotic functions. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, with differential mRNA accumulation in muscle and mammary tissue. STAT5 alpha is critically involved in reproduction, lactation, immune function, and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.