Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1C2), TrueMAB
인간 ALK 단백질을 인식하는 Rat 모노클로날 항체로, Western blot에 최적화됨. Lyophilized 형태이며 PBS, trehalose 버퍼로 안정화. 뇌 발달 관련 연구 및 ALK 변이 암 연구에 적합. 연구용으로만 사용 가능.
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Applications
Tested Dilution
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications of the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement often leads to a fusion gene between ALK and nucleophosmin (NPM), forming the oncogenic NPM-ALK fusion protein.
ALK is a receptor tyrosine kinase with transmembrane and extracellular domains, showing high similarity to LTK. It plays a key role in neuronal development and signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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