Thermo Fisher Scientific Phospho-TAK1 (Thr184, Thr187) Monoclonal Antibody (K.846.3)
TAK1 단백질의 Thr184 및 Thr187 인산화 상태를 검출하는 고특이성 단일클론 항체. Western blot 등 다양한 응용에 적합. Rabbit IgG 형식이며 비결합 상태로 제공. 고순도 정제 및 안정한 저장용액 구성.
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Thermo Fisher Scientific Phospho-TAK1 (Thr184, Thr187) Monoclonal Antibody (K.846.3)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.846.3 |
| Immunogen | Phosphopeptide corresponding to residues surrounding pThr184 and pThr187 of human TAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 24 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10982333 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-beta-activated kinase, TAK1 interacts with TGF-beta receptor and TRAF6 to modulate activation of JNK and p38. It also plays roles in Wnt, BMP, and activin signaling, as well as in responses to thyroid hormone, osmotic stress, endothelin, and ephrine.
Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 regulates PDGF-B and integrin expression, aiding proper wound healing. TAK1 is essential in IKK activation in pathways involving IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination, leading to TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, subsequently phosphorylating IKK-beta. TAK1 also represses human telomerase reverse transcriptase, implicating its role in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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