Thermo Fisher Scientific TrkB Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, keep aliquots at -20 °C for higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

NTRK2 (TrkB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. It is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.

TrkB is involved in the development and maintenance of the nervous system. It is a tyrosine kinase gene highly related to TrkA, with expression confined to tissues within the central and peripheral nervous systems. BDNF and NT-3 can induce rapid phosphorylation on tyrosine residues of TrkB gp145, though BDNF elicits a much stronger response. Upon neurotrophin binding, TrkB phosphorylates itself and members of the MAPK pathway, leading to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.