Thermo Fisher Scientific Occludin Recombinant Rabbit Monoclonal Antibody (JJ091-08)
Occludin 단백질 검출용 재조합 토끼 단일클론 항체. Western blot, Flow cytometry, Immunoprecipitation에 적합. Human 및 Mouse 시료에 반응. Protein A 정제, 1 mg/mL 농도, TBS 기반 buffer. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Flow Cytometry (Flow) | 1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ091-08 |
| Immunogen | Synthetic peptide within N-terminal human Occludin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931473 |
Target Information
Occludin is a 65 kDa protein that can exist in various phosphorylated forms (up to ~82 kDa). It plays a key role in regulating tight junction localization and function. Polyunsaturated fatty acids up-regulate occludin expression, enhancing transendothelial resistance and reducing permeability to large molecules. Expression levels vary by tissue: high and continuous in brain tissue at cell-cell contacts, lower and discontinuous in non-neural tissues. Occludin structure is highly conserved across species. Under-expression of occludin and other tight junction proteins contributes to increased vascular permeability in tumor endothelia, leading to brain tumor edema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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