Thermo Fisher Scientific STAT4 Recombinant Rabbit Monoclonal Antibody (JJ08-85)
STAT4 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 단일클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry, IP 등 다양한 실험에 적합. 높은 특이성과 재현성을 제공하며, IL-12 신호전달 및 Th1 반응 연구에 유용.
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Thermo Fisher Scientific STAT4 Recombinant Rabbit Monoclonal Antibody (JJ08-85)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:400 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ08-85 |
| Immunogen | Synthetic peptide within human STAT4 aa 700–748 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2931474 |
Target Information
STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein shares similarity with STAT1 (52%) and STAT3 (47%). Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2, forming homo- and heterodimers with related STAT family members. Tyrosine-phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.
STAT4 expression is restricted to the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which is essential for the T-cell independent induction of IFN-gamma and the development of Th1 responses necessary for defense against intracellular pathogens. STAT4-deficient mice exhibit impaired IL-12–mediated Th1 development and enhanced Th2 cell development. In viral infection, IFN-α/β activation of STAT4 is required for IFN-γ production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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