Thermo Fisher Scientific Aprutumab Recombinant Human Monoclonal Antibody

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Endotoxin level < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Aprutumab is a biosimilar that targets FGFR2.
FGFR2 is a member of the fibroblast growth factor receptor family and functions as a tyrosine-protein kinase receptor for fibroblast growth factors. It plays a key role in regulating cell proliferation, differentiation, migration, apoptosis, and embryonic development. FGFR family members differ in ligand affinities and tissue distribution.

Mutations in FGFR2 are associated with:

• Crouzon syndrome
• Pfeiffer syndrome
• Craniosynostosis
• Apert syndrome
• Jackson-Weiss syndrome
• Beare-Stevenson cutis gyrata syndrome
• Saethre-Chotzen syndrome
• Syndromic craniosynostosis

Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.