Thermo Fisher Scientific SRC Monoclonal Antibody (4F1E8)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1:10,000

Product Specifications

Product Specific Information

MA5-15398 targets SRC in indirect ELISA and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of SRC (aa10–193) expressed in E. coli.

Target Information

SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in regulation of embryonic development and cell growth. It associates with cytoplasmic regions of various cell surface receptors to facilitate signal transduction and plays roles in cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, SRC is encoded on chromosome 20. Its activity is regulated by phosphorylation at Tyr416 (activation) and Tyr527 (inhibition). Mutations in SRC may contribute to malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been identified.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.