Thermo Fisher Scientific CD276 Monoclonal Antibody (3E4)
인간 CD276(B7-H3)을 인식하는 Mouse IgG1 단클론 항체로, ELISA에 적합합니다. 비결합형 액상 형태이며, PBS(pH 7.4)에 보존제 없이 제공됩니다. 암 및 면역반응 연구용으로 사용되며, 세포 활성 및 사이토카인 생성 연구에 유용합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E4 |
| Immunogen | CD276 (AAH62581.1, 237 a.a. ~ 358 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ITPQRSPTGA VEVQVPEDPV VALVGTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA YANRTALFPD LLAQGNASLR LQRVRVADEG SFTCFVSIRD FGSAAVSLQV AA
Target Information
CD276 is a member of the B7 family of co-stimulatory molecules, also known as B7-H3.
It is a type I transmembrane protein that:
- Induces proliferation of CD4+ and CD8+ T cells
- Enhances generation of cytotoxic T cells
- Stimulates production of interferon gamma
Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines.
It is widely expressed in peripheral tissues including the heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
CD276 has therapeutic potential for regulating cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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