Thermo Fisher Scientific CD20 Monoclonal Antibody (2H7)
CD20 단백질을 인식하는 마우스 모노클로날 항체로, 인간 및 원숭이 시료에 반응합니다. WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합합니다. 단백질 A로 정제된 액상 제품이며, 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rhesus monkey |
| Published Species | Human, Non-human primate |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H7 |
| Immunogen | Proprietary Immunogen |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_927857 |
Additional Formats
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Mouse anti-Human CD20 antibody, clone 2H7 recognizes the human CD20 cell surface antigen, a 33–37 kDa non-glycosylated phosphoprotein.
Target Information
CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, a subpopulation of T lymphocytes, and follicular dendritic cells.
It regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 is associated with lipid rafts, with association intensity varying by extracellular stimuli and BCR aggregation.
After receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, while CD20 remains at the cell surface.
CD20 is a key target for antibody-mediated B-cell depletion, as it remains membrane-bound and is not internalized after antibody treatment.
Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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