Thermo Fisher Scientific STAT3/Signal Transducer and Activator of Transcription 3 Monoclonal Antibody (STAT3, 2409)
STAT3 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, 인간 시료에 반응합니다. IHC(P) 및 Peptide Array에 사용 가능하며, Protein A/G 정제된 액상 형태입니다. 세포 성장 및 신호전달 연구용으로 적합합니다.
- 카탈로그번호
- 6774-MSM2-P1ABX
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STAT3, 2409 |
| Immunogen | Recombinant human full-length STAT3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
STAT3 (Signal Transducer and Activator of Transcription 3) is a member of the STAT protein family. It is phosphorylated by receptor-associated kinases, translocates to the nucleus, and acts as a transcription factor in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for transcriptional activation by STAT3.
STAT3 can be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF, and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for dimer formation, nuclear translocation, and DNA binding. The human STAT3 gene is located on chromosome 17q. STAT3 is involved in regulating genes responsible for cell growth and apoptosis, and its deletion in mice is embryonically lethal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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