Thermo Fisher Scientific SDHD Polyclonal Antibody
Thermo Fisher Scientific의 SDHD Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Western blot 및 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제된 고품질 항체로, 미토콘드리아 SDHD 단백질 연구에 활용됩니다. 냉장 또는 -20°C 장기 보관 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 2.5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid synthetic peptide near the center of human SDHD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551739 |
Product Specific Information
A suggested positive control is EL4 cell lysate.
PA5-34387 can be used with blocking peptide PEP-1430.
Target Information
The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH).
Mutations in SDHD are associated with hereditary paragangliomas, typically benign tumors of the autonomic nervous system, suggesting a tumor-suppressor role for SDHD.
In one family with a nonsense mutation (R22X) in the SDHD gene, loss of heterozygosity was found in paragangliomas, and enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished.
High levels of angiogenic factors EPAS1 and VEGF were also observed, which may contribute to tumor growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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