Thermo Fisher Scientific Thioredoxin 1 Polyclonal Antibody
Thioredoxin 1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. 인간과 생쥐에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C 또는 -20°C에 보관합니다.
- 카탈로그번호
- PA534742
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 42–105 of Thioredoxin (Uniprot ID: P10599) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2552094 |
Product Specific Information
- Recommended positive controls: H1299, HeLaS3
- Predicted reactivity: Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Thioredoxins (Trx) are small, multifunctional proteins with oxidoreductase activity, present in nearly all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The cysteine residues can form intramolecular disulfide bonds, which are reduced by Trx reductase using NADPH. Reduced Trx acts as a hydrogen donor for ribonucleotide reductase, essential for DNA synthesis, and functions as a general protein disulfide reductase. Specific reduction targets include protein disulfide-isomerase (PDI) and transcription factors such as p53, NF-kB, and AP-1. Trx also contributes to H₂O₂ removal when coupled with methionine sulfoxide reductase or peroxiredoxins.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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