Thermo Fisher Scientific Bax (Apoptosis Marker) Monoclonal Antibody (2D2)
인간 및 비인간 영장류 반응성 Bax 단백질을 인식하는 단클론 항체로, apoptosis 연구에 적합합니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. 단백질 A/G 정제, 4°C 보관, 비결합형 액상 제품.
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Thermo Fisher Scientific Bax (Apoptosis Marker) Monoclonal Antibody (2D2)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Immunomicroscopy (IM) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D2 |
| Immunogen | Synthetic peptide, aa 3–16 (Cys-GSGEQPRGGGPTSS) of human Bax protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Mouse or Rat.
Target Information
BAX is a member of the Bcl-2 family and plays an important role in the regulation of apoptosis. While Bcl-2 acts as an anti-apoptotic protein, BAX promotes apoptosis through homo- and heterodimerization with other Bcl-2 family proteins.
The Bax gene encodes isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa). Both contain BH1, BH2, and BH3 domains, but Bax beta lacks a hydrophobic transmembrane domain.
Overexpression of BAX promotes cell death and it can form homodimers or heterodimers with other BCL-2 related proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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