Thermo Fisher Scientific Phospho-CHK2 (Ser33, Ser35) Recombinant Superclonal Antibody (2HCLC)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, and Rabbit.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of a selection of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies, and delivering the consistency only found in recombinant antibodies.

While functionally similar to polyclonal antibodies—recognizing multiple epitope sites and providing higher detection sensitivity for low-abundance targets—Recombinant Superclonal™ antibodies have a defined mixture of light and heavy chains, ensuring reproducibility across lots.

Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. Product performance remains unchanged.

Target Information

CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are associated with various cancers. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control, including tumor suppressor proteins. It can phosphorylate BRCA1, aiding in DNA damage recovery.

CHK2 acts as a tumor suppressor, with mutations linked to Li-Fraumeni syndrome and predisposition to sarcomas, breast cancer, and brain tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.