Thermo Fisher Scientific Caveolin-1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Caveolin-1. Validated for WB, ELISA, and IP applications. Affinity purified, unconjugated liquid form with 0.68 mg/mL concentration. Suitable for research use with broad species cross-reactivity.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-Caveolin 1 affinity purified antibody prepared from whole rabbit serum, produced by repeated immunizations with a synthetic peptide at the N-terminus of human Caveolin-1 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.68 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 30% glycerol, 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid repeated freeze/thaw cycles.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
A BLAST analysis suggests cross-reactivity with sheep, primate, bat, rat, rabbit, mouse, elephant, horse, human, cat, armadillo, and hedgehog based on 100% sequence homology. Cross-reactivity with Caveolin-1 from other sources has not been determined.
Target Information
Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes that interacts directly with G-protein alpha subunits, regulating their activity. It participates in co-stimulatory signaling essential for T-cell receptor (TCR)-mediated activation, binding with DPP4 to induce T-cell proliferation and NF-kappa-B activation. Mutations in the CAV1 gene are associated with congenital generalized lipodystrophy 3, primary pulmonary hypertension 3, and partial lipodystrophy/congenital cataracts with neurodegeneration syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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