Thermo Fisher Scientific Caveolin-1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid repeated freeze/thaw cycles.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

A BLAST analysis suggests cross-reactivity with sheep, primate, bat, rat, rabbit, mouse, elephant, horse, human, cat, armadillo, and hedgehog based on 100% sequence homology. Cross-reactivity with Caveolin-1 from other sources has not been determined.

Target Information

Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes that interacts directly with G-protein alpha subunits, regulating their activity. It participates in co-stimulatory signaling essential for T-cell receptor (TCR)-mediated activation, binding with DPP4 to induce T-cell proliferation and NF-kappa-B activation. Mutations in the CAV1 gene are associated with congenital generalized lipodystrophy 3, primary pulmonary hypertension 3, and partial lipodystrophy/congenital cataracts with neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.