Thermo Fisher Scientific TWIST1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000–1:20,000

Product Specifications

Product Specific Information

• Positive Control: Flag-human TWIST1-transfected HeLa cells
• Predicted Reactivity: Mouse (93%), Rat (93%), Chicken (82%), Chimpanzee (99%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

TWIST1 acts as a transcriptional regulator. It inhibits myogenesis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction.
TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B.
Additionally, TWIST1 regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition.
Mutations in the gene are implicated in Saethre-Chotzen syndrome, characterized by cranial and facial abnormalities.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.