Thermo Fisher Scientific HLA-DR/DQ Monoclonal Antibody (28.1), PE

Applications

• Flow Cytometry (Flow)
  Tested Dilution: Neat–1:10

Product Specifications

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store undiluted at 4°C in the dark.
• For FACS analysis, use 10 µL of the working dilution to label 1×10⁶ cells in 100 µL.

Target Information

The major histocompatibility complex (MHC) is a cluster of genes important in immune response to infections.
In sheep, this is referred to as the ovine leukocyte antigen (OLA) region.
There are two major types of MHC class IIa molecules encoded by OLA — DR and DQ — each composed of an alpha and beta chain.
The polymorphic epitope on ovine MHC class II DQ and DR molecules is constitutively expressed on antigen-presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, and activated T lymphocytes, and may be induced on other cell types by interferon gamma.

HLA and MHC antibodies play a significant role in immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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