Thermo Fisher Scientific CD27 Recombinant Rabbit Monoclonal Antibody (JB40-98)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive Control: Raji, Daudi, K562, human tonsil tissue, rat spleen tissue.

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. Members of the TNF superfamily regulate cell proliferation and death. CD27 and its ligand CD70 are mainly expressed in lymphocytes. High CD27 expression depends on antigen receptor ligation, while CD70 expression requires co-stimulatory or pro-inflammatory signals.

CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. T cell activation via the TCR-CD3 complex induces upregulation of CD27 and release of its soluble form (sCD27), detectable in plasma, urine, or spinal fluid. Soluble CD27 serves as a prognostic marker for acute and chronic B cell malignancies. RgpA, a cysteine proteinase, can degrade CD27 and counteract CD27/CD70-mediated T cell activation. CD27-binding protein (SIVA) is a proapoptotic protein that interacts with CD27 and contributes to receptor-induced apoptosis.

Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.