Thermo Fisher Scientific SEPN1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 86%
Guinea Pig: 86%
Horse: 86%
Human: 100%
Mouse: 86%
Rat: 86%

Target Information

SEPN1 is a selenoprotein that contains a selenocysteine (Sec) residue at its active site. Mutations in the SEPN1 gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome.
The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3′ UTR of selenoprotein genes contains a stem-loop structure (SECIS) necessary for recognition of UGA as a Sec codon rather than a stop signal.
Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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