Thermo Fisher Scientific ARTS1 Recombinant Rabbit Monoclonal Antibody (ARC2120)

Applications

Product Specifications

Product Specific Information

• Positive Samples: HepG2, Jurkat, Mouse lung, Mouse liver, Rat liver
• Immunogen sequence:
  NPVGYPLAWQ FLRKNWNKLV QKFELGSSSI AHMVMGTTNQ FSTRTRLEEV KGFFSSLKEN GSQLRCVQQT IETIEENIGW MDKNFDKIRV WLQSEKLERM

Target Information

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the ER lumen. It removes NH₂-terminal residues from antigenic precursors for MHC class I peptide presentation. ERAP1 trims peptides of 9 amino acids or more and is induced by interferon-gamma.
The human ERAP1 gene maps to chromosome 5q15 and is also known as A-LAP, PILS-AP, and ARTS-1.

• A-LAP: Inactivates bioactive peptides such as angiotensin II, potentially regulating blood pressure.
• PILS-AP: Involved in angiogenesis by regulating endothelial cell proliferation and migration.
• ARTS-1: TNFR1 binding protein promoting TNFR1 shedding.

Further research is required to fully elucidate the functions of this protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.