Thermo Fisher Scientific PERP Recombinant Rabbit Monoclonal Antibody (ARC2094)
PERP 단백질을 인식하는 재조합 토끼 모노클로날 항체로, WB, IHC, ICC/IF, ELISA에 적합합니다. 인간, 생쥐, 랫드 시료에 반응하며, p53 유도 세포사멸 연구에 활용됩니다. 고순도 친화 크로마토그래피 정제 및 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:400 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2094 |
| Immunogen | Synthetic peptide corresponding to amino acids 94–193 of human PERP (Q96FX8) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898066 |
Product Specific Information
- Positive Samples: HepG2, BxPC-3, A-431, Mouse liver, Mouse kidney, Rat lung, Rat liver
- Immunogen sequence:
LSFFALCGPQ MLVFLRVIGG LLALAAVFQI ISLVIYPVKY TQTFTLHANP AVTYIYNWAY GFGWAATIIL IGCAFFFCCL PNYEDDLLGN AKPRYFYTSA
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP, and PERP, have been identified and cloned.
PERP (also known as PIGPC1 and THW) is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates the PERP gene, and the translated PERP protein mediates p53-induced apoptosis. The expression of PERP causes cell death, acting as a mediator of p53-induced apoptosis. PERP shares sequence similarity with PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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