Thermo Fisher Scientific PERP Recombinant Rabbit Monoclonal Antibody (ARC2094)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:100-1:400

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC2094

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 94-193 of human PERP (Q96FX8) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PERP,uniProtId:Q96FX8-1,ncbiNodeId:9606,antigenRange:94-193,antigenLength:193,antigenImageFileName:MA5-38148_PERP_Q96FX8-1_Rabbit.svg,antigenImageFileNamePDP:MA5-38148_PERP_Q96FX8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898066

Product Specific Information

Positive Samples: HepG2, BxPC-3, A-431, Mouse liver, Mouse kidney, Rat lung, Rat liver

Immunogen sequence: LSFFALCGPQ MLVFLRVIGG LLALAAVFQI ISLVIYPVKY TQTFTLHANP AVTYIYNWAY GFGWAATIIL IGCAFFFCCL PNYEDDLLGN AKPRYFYTSA

Target Information

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.