Thermo Fisher Scientific RPSA Recombinant Rabbit Monoclonal Antibody (ARC2109)
RPSA 단백질을 인식하는 토끼 유래 재조합 단일클론 항체로 Western blot, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 Affinity chromatography로 정제되었습니다. 안정한 액상 형태로 -20°C에서 보관 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2109 |
| Immunogen | Synthetic peptide corresponding to amino acids 196–295 of human Laminin Receptor (P08865) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898071 |
Product Specific Information
- Positive Samples: PC-12, A-549, BxPC-3, Raji, RAW264.7, Rat pancreas
- Immunogen Sequence:
EVMPDLYFYR DPEEIEKEEQ AAAEKAVTKE EFQGEWTAPA PEFTATQPEV ADWSEGVQVP SVPIQQFPTE DWSAQPATED WSAAPTAQAT EWVGATTDWS
Target Information
Laminins are extracellular matrix glycoproteins that form a major component of basement membranes. They play roles in cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. These effects are mediated through interactions with cell surface receptors, including integrins and non-integrin laminin-binding proteins.
The Laminin Receptor 1 (RPSA) is a high-affinity, non-integrin laminin receptor, also known as 67 kDa laminin receptor, 37 kDa laminin receptor precursor (37LRP), or p40 ribosome-associated protein. Its sequence is highly conserved, indicating an essential biological role. Elevated expression has been observed in colon carcinoma and lung cancer cells, correlating with invasive and metastatic phenotypes. Multiple pseudogene copies exist, and two alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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