Thermo Fisher Scientific SOCS1 Polyclonal Antibody
SOCS1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, 인간 및 마우스 등 다양한 종에 반응합니다. Western blot, IHC, ELISA, IP 등 여러 응용에 적합하며, 액상 형태로 고순도 친화 크로마토그래피 정제된 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 170–212 of human Suppressor of Cytokine Signaling 1 (SOCS1) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Suppressor of Cytokine Signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular regulators that modulate immune cell responses to cytokines.
SOCS1 inhibits dendritic cell and T cell hyperactivation by binding to JAK tyrosine kinase, preventing cytokine receptor signaling.
Additionally, SOCS1 exhibits E3 ubiquitin ligase activity, promoting polyubiquitination and degradation of target proteins via the proteasome.
Through this mechanism, SOCS1 negatively regulates Toll-like receptor (TLR2 and TLR4) signaling by mediating degradation of the adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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