Thermo Fisher Scientific SOCS3 Polyclonal Antibody
SOCS3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 고순도 Affinity chromatography 정제, -20°C 보관. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 175–225 on human SOCS3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). There are eight members of the SOCS family: SOCS-1, SOCS-2, SOCS-3, SOCS-4, SOCS-5, SOCS-6, SOCS-7, and CIS. Structurally, SOCS proteins consist of an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box motif. These proteins form a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. SOCS gene transcription occurs rapidly in response to cytokines, and the SOCS proteins inhibit signaling through different mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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