Thermo Fisher Scientific LECT1 Polyclonal Antibody
Western blot과 ICC/IF에 적합한 다클론성 항체로 인간 및 생쥐 시료에 반응. 항원 친화 크로마토그래피로 정제되어 높은 순도(>95%) 확보. PBS/glycerol 완충액에 보관되며 단기 4°C, 장기 -20°C 저장 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | — |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human LECT1 (amino acids 1–334, UniProt ID: O75829-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C for short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2720701 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
ChM-1 is a cartilage-specific matrix glycoprotein that stimulates the growth of chondrocytes. It inhibits angiogenesis by disrupting endothelial cell tube formation, contributing to the avascular nature of cartilage. ChM-1 is strongly expressed in the proliferating and hypertrophic zones of the epiphyseal plate in long bones and accumulates in the interterritorial matrix around the lacunae. During development, downregulation of ChM-1 permits angiogenesis and bone formation on the cartilage template. Its expression is downregulated by growth factors such as TGFβ2, FGF2, and PTHLH, and may play a role in the hypovascularity and chondroid formation of pleomorphic adenomas. The human ChM-1 gene maps to chromosome 13q14–q21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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