Thermo Fisher Scientific CD40 Recombinant Rabbit Monoclonal Antibody (5V8X7)

Applications and Tested Dilution

Product Specifications

Product Specific Information

The target is usually found in the following locations:

• Cell membrane
• Secreted
• Single-pass type I membrane protein

Immunogen sequence:
EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR

Target Information

The CD40 antigen is a single-chain glycoprotein belonging to the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin’s disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells, and also found on epithelial cells, carcinomas, and lymphoid dendritic cells.

CD40 plays a crucial role in immune and inflammatory responses, including:

• T cell-dependent immunoglobulin class switching
• Memory B cell development
• Germinal center formation

AT-hook transcription factor AKNA regulates CD40 expression, facilitating homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and mediates signal transduction. The CD40–CD40L interaction is necessary for amyloid-beta-induced microglial activation, an early event in Alzheimer’s disease pathogenesis.

Two alternatively spliced transcript variants encoding distinct CD40 isoforms have been reported. Diseases associated with CD40 dysfunction include:

• Type 3 Hyper-IgM immunodeficiency
• CD40 ligand deficiency

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.