Thermo Fisher Scientific PSME2 Monoclonal Antibody (3F11-1A3)

Thermo Fisher Scientific PSME2 Monoclonal Antibody (3F11-1A3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SLNVADLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKV LSLLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAYG ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY

Target Information

Proteolytic degradation maintains appropriate levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle, transcription, and signaling. The ubiquitin-proteasome pathway deconstructs most cytosolic and nuclear proteins, while others are degraded via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (~31) molecular machine (~2.5 MDa) consisting of a 20S proteolytic core complex and 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and facilitate unfolding and translocation into the 20S core. Defects in this pathway are linked to diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.