Thermo Fisher Scientific LAP1 Monoclonal Antibody (RL13)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

RL13

Immunogen

Pore complex-lamina fraction isolated from rat liver nuclear envelopes. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TOR1AIP1,uniProtId:Q5PQX1-1,ncbiNodeId:10114,antigenRange:1-583,antigenLength:583,antigenImageFileName:MA1-074_TOR1AIP1_Q5PQX1-1_House_mouse.svg,antigenImageFileNamePDP:MA1-074_TOR1AIP1_Q5PQX1-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2056886

Product Specific Information

MA1-074 detects lamin associated polypeptide (LAP) 1A, 1B & 1C from rat, human, and mouse samples. This antibody does not cross-react with LAP 2.

MA1-074 has been successfully used in Western blot, immunofluorescence, immunohistochemistry, and immunoprecipitation procedures. By Western blot, this antibody detects 3 distinct proteins of molecular weights ~65, ~56 and ~ 51 kDa representing LAP 1A, 1B, and 1C, respectively in rat liver nuclear envelope fractions. Immunofluorescence staining of LAP 1 in rat liver with MA1-074 results in exclusive labeling of the nuclear periphery and exhibits co-localization with lamin staining.

The MA1-074 immunogen is pore complex-lamina fraction isolated from rat liver nuclear envelopes.

Target Information

Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.