Thermo Fisher Scientific S100B Monoclonal Antibody (SP127)
인간 S100B 단백질을 인식하는 Rabbit 모노클론 항체로, IHC(P) 및 유세포분석에 사용 가능. 고순도 Protein A/G 정제, 액상 형태, 0.22 mg/mL 농도. 신경계 및 멜라노마 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Flow Cytometry (Flow) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SP127 |
| Immunogen | Full length recombinant human S100 beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.22 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.6, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537915 |
Product Specific Information
A suggested positive control is colon or melanoma tissue.
Target Information
S100B is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. These proteins are localized in the cytoplasm and/or nucleus of various cells and regulate cellular processes such as cell cycle progression and differentiation.
S100B may function in neurite extension, melanoma cell proliferation, stimulation of Ca²⁺ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly.
Chromosomal rearrangements and altered expression of this gene have been implicated in diseases such as Alzheimer’s disease, Down’s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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