Thermo Fisher Scientific beta Arrestin 1 Recombinant Rabbit Monoclonal Antibody (23GB1755)
Human 및 Mouse 시료에 반응하는 재조합 토끼 단일클론 항체로, Western blot, ICC/IF, Flow Cytometry에 사용 가능. HEK293F 발현 시스템에서 생산되며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관하며 -20°C에서 안정적.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1755 |
| Immunogen | A synthesized peptide derived from human ARRB1 (1–48 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Beta Arrestin 1 is a member of a family of proteins widely expressed, particularly in the central nervous system. Acting as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of G-protein-coupled receptors (GPCRs), such as the beta 2-adrenergic receptor.
Upon ligand binding and G-protein interaction, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1/2 on serine 412 in a negative feedback mechanism, then binds to phosphorylated receptors at the plasma membrane. Serine 412 is subsequently dephosphorylated, leading to GPCR internalization and activation of the Ras–Raf–ERK1/2 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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