Thermo Fisher Scientific Amyloid Precursor Protein Recombinant Rabbit Monoclonal Antibody (23GB1535)
Thermo Fisher의 재조합 토끼 단클론 항체로, 인간·마우스·랫트의 Amyloid Precursor Protein(APP)을 검출합니다. Western blot, ICC/IF, Flow cytometry에 적합하며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1535 |
| Immunogen | A synthesized peptide derived from human Amyloid beta A4 (700–770AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating axonal transport of beta-secretase and presenilin 1. APP is crucial for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with several isoforms generated by alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques—major histopathologic features of Alzheimer’s disease. Abnormal APP regulation and processing are implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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