Thermo Fisher Scientific Human G-CSF, Animal-Free Recombinant Protein, PeproTech
동물 유래 성분이 없는 인간 G-CSF 재조합 단백질로, 세포 증식 및 분화 연구에 적합합니다. ≥98% 고순도, 낮은 엔도톡신 수준(<0.1 EU/µg), E. coli 발현 시스템 사용. NFS-60 세포 증식 활성 검증 완료. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- AF-300-23-xxxxx (3개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human G-CSF, Animal-Free Recombinant Protein, PeproTech
Applications
- Western Blot (WB): Assay-dependent
- ELISA: Assay-dependent
- Functional Assay: Assay-dependent
- In vitro Assay: Assay-dependent
- Miscellaneous PubMed: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse, Plant |
| Expression System | E. coli |
| Amino Acid Sequence | TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP |
| Molecular Weight | 18.7 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | Stimulates proliferation of mouse NFS-60 cells (ED50 ≤ 0.1 ng/ml, ≥ 1×10⁷ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human G-CSF is an 18.7 kDa protein consisting of 174 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
G-CSF (Granulocyte Colony Stimulating Factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes.
Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described.
This pleiotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells. It influences proliferation, differentiation, and activation of hematopoietic cells.
G-CSF is also expressed by various transformed cells such as carcinoma and myeloblastic leukemia cells.
G-CSF is encoded by two distinct DNA sequences, resulting in full-size (high activity) and shorter (low activity) isoforms. It is highly conserved among species and exerts biological functions through interaction with its receptor expressed on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.
Clinically, G-CSF is used in therapies for neonatal infections, acute myocardial infarction, granulocyte transfusion in neutropenia, severe infections and sepsis, chronic autoimmune neutropenia, acute myeloid leukemia, Sweet’s syndrome, and AIDS.
It is also a marker protein for carcinomas such as bladder cancer, and dysfunction of G-CSF is linked to Kostmann Syndrome.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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