Thermo Fisher Scientific FICD Monoclonal Antibody (OTI11E11), TrueMAB
인간 FICD 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot에 최적화되어 있으며, 비결합형 동결건조 형태로 제공. ER 스트레스 관련 단백질 HSPA5/BiP의 AMPylation 연구에 유용. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11E11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 61–265 of human FICD produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Protein that mediates both AMPylation (addition of adenosine 5'-monophosphate) and de-AMPylation (removal of AMP) of target proteins, depending on the context.
The side chain of Glu-231 determines whether AMPylase or de-AMPylase activity occurs.
Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by modulating the AMPylation state of HSPA5/BiP.
In unstressed cells, it AMPylates HSPA5/BiP at Thr-518, inactivating it. Under ER stress, it removes AMP from HSPA5/BiP at the same site, restoring activity.
Although capable of AMPylating RhoA, Rac, and Cdc42 in vitro, these are not physiological substrates.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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