Thermo Fisher Scientific FICD Monoclonal Antibody (OTI3E3), TrueMAB

Thermo Fisher Scientific FICD Monoclonal Antibody (OTI3E3), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution: 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Protein that mediates both AMPylation (addition of adenosine 5'-monophosphate to target proteins) and de-AMPylation (removal of AMP) depending on context.
Glu-231 determines the AMPylase or de-AMPylase activity.
Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by modulating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083).
In unstressed cells, AMPylates HSPA5/BiP at Thr-518 to inactivate it; under ER stress, removes AMP to restore activity.
Although capable of AMPylating RhoA, Rac, and Cdc42 in vitro, these are not physiological substrates (PubMed:19362538, PubMed:25601083).
[UniProt]

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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