Thermo Fisher Scientific FICD Monoclonal Antibody (OTI3E3), TrueMAB
인간 FICD 단백질(aa 61-265)에 특이적인 Mouse IgG1 단일클론 항체. Western blot에 검증됨. 동결건조 형태로 제공되며 PBS/trehalose 버퍼에 저장. ER 스트레스 관련 단백질 AMPylation 연구에 적합.
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Thermo Fisher Scientific FICD Monoclonal Antibody (OTI3E3), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 61–265 of human FICD produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Protein that mediates both AMPylation (addition of adenosine 5'-monophosphate to target proteins) and de-AMPylation (removal of AMP) depending on context.
Glu-231 determines the AMPylase or de-AMPylase activity.
Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by modulating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083).
In unstressed cells, AMPylates HSPA5/BiP at Thr-518 to inactivate it; under ER stress, removes AMP to restore activity.
Although capable of AMPylating RhoA, Rac, and Cdc42 in vitro, these are not physiological substrates (PubMed:19362538, PubMed:25601083).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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