Thermo Fisher Scientific FBXO8 Monoclonal Antibody (OTI4C6), TrueMAB

Applications

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The FBXO8 gene encodes a member of the F-box protein family, characterized by a ~40 amino acid F-box motif. These proteins form part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex, which mediates phosphorylation-dependent ubiquitination.
F-box proteins are classified into:

• Fbws: containing WD-40 domains
• Fbls: containing leucine-rich repeats
• Fbxs: containing other interaction modules or no recognizable motifs

FBXO8 belongs to the Fbxs class and includes a C-terminal region similar to yeast Sec7p, a regulator of vesicular protein transport. The human FBXO8 protein may interact with ADP-ribosylation factors (ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.