Thermo Fisher Scientific HIC1 Monoclonal Antibody (4E11)
HIC1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 4E11). Western blot, ICC/IF, ELISA에 적합하며 인간 및 랫트 시료에서 반응. PBS buffer에 보관, 냉동(-20°C) 상태로 안정적 유지.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E11 |
| Immunogen | HIC1 (NP_006488, 396–453 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
YKSSSEETGS SEDPSPPGGH LEGYPCPHLA YGEPESFGDN LYVCIPCGKG FPSSEQLN
Target Information
Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and its expression is frequently suppressed in leukemia and various cancers due to hypermethylation of specific DNA regions, leading to transcriptional silencing.
HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. It is ubiquitously expressed in adult tissues and characterized by five zinc fingers and an N-terminal broad complex POZ (BTB) domain.
In other BTB/POZ-containing proteins such as BCL-6 and PLZF, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex, repressing gene transcription. However, HIC-1 does not interact with HDAC components, suggesting its transcriptional repression is independent of the POZ/BTB domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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