Thermo Fisher Scientific IL-15 Polyclonal Antibody
Thermo Fisher Scientific의 IL-15 Polyclonal Antibody는 마우스 IL-15를 특이적으로 인식하는 염소 유래 IgG 항체입니다. Western blot, IHC(F), ICC/IF, Neutralization에 사용 가능하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 면역 반응 및 세포 활성 연구에 적합합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–15 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Neutralization (Neu) | 0.4–2.4 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse IL-15 (Asn49–Ser162) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608699 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 15% cross-reactivity with recombinant human IL-15 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of antibody by the LAL method.
Target Information
IL-15 (Interleukin 15) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities, binding common hematopoietin receptor subunits and potentially competing for the same receptor, thereby negatively regulating each other’s activity.
IL-15 induces activation of JAK kinases and phosphorylation of STAT3, STAT5, and STAT6 transcription activators. In mouse studies, IL-15 may increase expression of apoptosis inhibitor Bcl-xL, preventing apoptosis.
It plays a crucial role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes, and is involved in immune responses, allograft rejection, and autoimmune disease pathogenesis.
IL-15 is a pro-inflammatory cytokine implicated in disorders such as rheumatoid arthritis, psoriasis, and pulmonary inflammation. Neutralization of IL-15 shows therapeutic potential in models of psoriasis and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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