Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1C6), TrueMAB
인간 ALK 단백질을 특이적으로 인식하는 Rat 모노클로날 항체로, Western blot에 최적화됨. TrueMAB 형식의 고순도 항체로 1 mg/mL 농도 제공. PBS, BSA, 글리세롤 완충액에 보존되며 -20°C에서 안정적 저장 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications of the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement often produces a fusion gene combining the ALK gene (chromosome 2) and the nucleophosmin (NPM) gene (chromosome 5), resulting in the oncogenic NPM-ALK fusion protein. ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK, and plays a key role in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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